Retinoblastoma, the visible CNS tumor: A review
نویسندگان
چکیده
منابع مشابه
A review of retinoblastoma disease
Retinoblastoma is a rare type of eye cancer that usually occurs in early childhood, usually before the age of five. This type of cancer occurs in the retina, the light-sensitive tissue behind the eye that recognizes light and color. It is the most common type of eye cancer in children. One-third of all retinoblastomas are inherited, meaning that mutations in the RB1 gene are present in all cell...
متن کاملRetinoblastoma: a Review
Retinoblastoma is the most common intraocular malignancy of childhood, yet over all it is relatively rare, affecting 1 in 78,000 to 30,000 live births. The prognosis for life is 92 percent if the tumor is detected early; however, greater than 95 percent mortality is documented for cases with advanced presentation. This paper discusses incidence, diagnosis, histopathology, and treatment of retin...
متن کاملThe Retinoblastoma Tumor Suppressor Regulates a Xenobiotic Detoxification Pathway
The retinoblastoma tumor suppressor (pRb) regulates cell cycle entry, progression and exit by controlling the activity of the E2F-family of transcription factors. During cell cycle exit pRb acts as a transcriptional repressor by associating with E2F proteins and thereby inhibiting their ability to stimulate the expression of genes required for S phase. Indeed, many tumors harbor mutations in th...
متن کاملthe expression of retinoblastoma tumor suppressor protein in oral cancers and precancers: a clinicopathological study
background: the role of retinoblastoma (rb) protein in cell cycle regulation prompted us to take up this study with the aim of assessing its role in the progression of oral cancer and to correlate with various clinicopathological parameters, including habits such as smoking, paan chewing, and alcoholism. materials and methods: this observational study included surgical specimens from 10 apparen...
متن کاملLipid based nanoparticles for treatment of CNS diseases: review Article
Introduction: Central Nervous System (CNS) is one of the most important organs which is managing so many functions in human body. So, impairment of its function may results in several disorders in body, or CNS diseases, which are considered very important. CNS diseases are divided into many different groups and each group is treated with its own related medication. Some drugs that are used for ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2018
ISSN: 0360-4012
DOI: 10.1002/jnr.24213